Pharmacological effect
1. Targets: SSTR2, SSTR5 (somatostatin receptor 2/5), highly selective activation; Low affinity for SSTR1/3/4 Somatuline...
2. Inhibit the secretion of growth hormone GH by the pituitary gland and reduce IGF-1: It is used for acromegaly, shrink pituitary growth hormone tumors, and improve symptoms related to acromegaly (enlarged hands and feet, facial changes, excessive sweating)
3. Inhibit the release of various gastrointestinal/neuroendocrine hormones: glucagon, gastrin, VIP, 5-hydroxytryptamine, etc. Control gastroenteropancreatic neuroendocrine tumor GEP-NET (carcinoid), alleviate symptoms of carcinoid syndrome such as flushing and diarrhea, inhibit tumor proliferation and reduce tumor blood supply
4. The half-life of natural somatostatin is only a few minutes. Lanrepeptide is a cyclic peptide, and the stability of the enzyme has been significantly enhanced. Sustained-release microsphere/nanotube preparations, deep intramuscular injection every 4 weeks
IDA