1.Glp-1 receptor activation
◦ Central nervous system: It acts on the satiety center of the hypothalamus, inhibits appetite, increases satiety, and reduces food intake
◦ Gastrointestinal tract: Delays gastric emptying; Pancreas: Glucose-dependent insulin secretion promotes, inhibits improper glucagon release, lowers blood sugar, and reduces HbA1c
2.Glucagon GCGR receptor activation (Core Feature)
◦ Liver: Promotes β -oxidation of fatty acids in the liver, directly reduces fat accumulation in the liver, alleviates liver inflammation, and improves liver fibrosis, targeting MASH (metabolism-related steatohepatitis); This liver effect has a considerable proportion that does not rely on weight loss, which is the greatest advantage over GLP-1 drugs alone
Overall: It enhances resting energy expenditure, promotes the breakdown of visceral fat, and has a stronger weight loss effect with less lean body mass loss