It activates the amylin receptor and calcitonin receptor, acts on the posterior brainstem area, enhances satiety, suppresses appetite, reduces food intake, and achieves weight loss effects.
2. Delay gastric emptying: Slow down the speed at which food in the stomach enters the small intestine, preventing a rapid spike in post-meal blood sugar and helping to control post-meal blood sugar.
3. The half-life of natural amylin is very short (several minutes); Cagrilintide, through the acylation modification of fatty acid side chains, can bind to albumin, significantly extending its half-life and enabling subcutaneous injection once a week.
4. Core combination formulation CagriSema = Cagrilintide + Semaglutide: It simultaneously activates the amylin pathway and the GLP-1 pathway, with combined effects of weight loss and blood sugar reduction. It is currently a popular investigational compound drug for obesity and type 2 diabetes.
IDA