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Teduglutide

Product Item : CAS 197922-42-2
Category： peptides
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Pharmacological effect

1. Target: GLP-2 receptor, intestinal nutritional polypeptide (intestinal-stimulating nutritional hormone). Natural GLP-2 is highly susceptible to rapid degradation by DPP-4. Teduglutide was replaced with Gly at the 2nd Ala to resist the hydrolysis of DPP-4, and its half-life was extended to approximately 1.3 hours.

2. Core intestinal growth-promoting effect: Stimulates the small intestinal mucosa, increases the height of villi, deepens the depth of crypts, promotes the proliferation of intestinal epithelium, reduces epithelial apoptosis, and increases the absorption area of the residual intestine. Improve intestinal barrier and increase intestinal blood flow (PMC)

3. Other effects: Inhibits gastric emptying, reduces gastric acid secretion, slows intestinal transport, and increases the absorption of water, electrolytes, and nutrients.

Indications: Short bowel syndrome (SBS), adults and children over 1 year old, patients relying on parenteral nutrition/intravenous fluid replacement; The goal is to reduce the dosage of parenteral nutrition support and help the intestine compensate and restore its absorption capacity, DailyMed

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