Pharmacological effect
1. Target: Intestinal epithelial GC-C receptor, mimics endogenous uroguanylin, only takes effect locally in the intestine and hardly enters the bloodstream. National C...
2. Activation of GC-C → Increase of intracellular cGMP → activation of CFTR channels, secreting chloride ions and bicarbonate into the intestinal lumen, increasing intestinal water content and softening feces; At the same time, it inhibits the sodium-hydrogen exchange of NHE3, reduces the reabsorption of intestinal water, accelerates intestinal transport, and promotes defecation PMC
3. Extracellular cGMP can reduce the sensitivity of visceral pain nerves in the intestinal tract, alleviate abdominal pain and distension in patients with IBS-C, and also promote defecation and relieve intestinal pain. FDA Access...
IDA