Target: IRR (Innate Repair receptor, EPOR/CD131 (β -Common receptor) heterodimer)
Natural EPO simultaneously activates EPOR homodimer (promoting erythropoiesis and raising hemoglobin) and IRR (tissue protection). Cibinetide only selectively activates IRR, has no hematopoietic activity at all, and does not increase red blood cells/hemoglobin. This is its most core design highlight. excaliburp... .
2. Tissue protection, anti-inflammatory, and nerve repair
Inhibit NF - κB and NLRP3 inflammasomes, reduce pro-inflammatory factors such as TNF - α and IL-6, and alleviate tissue inflammatory damage;
Protect Schwann cells, promote the regeneration of fine nerve fibers, increase the density of corneal nerve fibers, and improve neuralgia caused by small fiber neuropathy;
Preclinical manifestations show multiple tissue repair effects such as renal protection, intestinal mucosal protection, inhibition of osteoclasts, and increase in bone density.
IDA